MiR-29a/b/c function as invasion suppressors for gliomas by targeting CDC42 and predict the prognosis of patients.

ABSTRACT:

Background

The lethality and poor outcome of high-grade gliomas result from the tumour relentless invasion. miR-29a/b/c downexpressions contribute to several human tumourigenesis. However, their relevance to prognosis and invasion in gliomas remains unclear.

Methods

Relationships of miR-29a/b/c and CDC42 expressions to grade and survival-time in 147 human gliomas were analysed by in situ hybridisation and immunohistochemistry. Dual-luciferase reporter assay was used to identify CDC42 as a target of miR-29a/b/c. Underlining mechanisms by which miR-29a/b/c inhibited glioma cell migration and invasion were studied by in vitro and in vivo assays.

Results

miR-29a/b/c expressions were inversely correlated with glioma grades, but positively correlated with patients' survival

SUBMITTER: Shi C 

PROVIDER: S-EPMC5625669 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature