Influence of dietary insulin scores on survival in colorectal cancer patients.

ABSTRACT:

Background

Although hyperinsulinemia is hypothesised to be involved in colorectal carcinogenesis, it remains unclear whether a diet inducing an elevated insulin response influences colorectal cancer (CRC) survival.

Methods

We examined the association of post-diagnosis dietary insulin scores with survival among 2006 patients from two large prospective cohorts who were diagnosed with CRC from 1976 to 2010. Dietary insulin load was calculated as a function of the food insulin index. Dietary insulin index was calculated by dividing insulin load by total energy intake. Cox proportional hazards models were used to calculate hazard ratios (HRs) for CRC-specific mortality and overall mortality, adjusted for other risk factors for cancer survival.

Results

The adjusted HRs for

SUBMITTER: Yuan C 

PROVIDER: S-EPMC5625675 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature