Efficacy of rabies vaccines in dogs and cats and protection in a mouse model against European bat lyssavirus type 2.

ABSTRACT:

Background

Rabies is preventable by pre- and/or post-exposure prophylaxis consisting of series of rabies vaccinations and in some cases the use of immunoglobulins. The success of vaccination can be estimated either by measuring virus neutralising antibodies or by challenge experiment. Vaccines based on rabies virus offer cross-protection against other lyssaviruses closely related to rabies virus. The aim was to assess the success of rabies vaccination measured by the antibody response in dogs (n = 10,071) and cats (n = 722), as well as to investigate the factors influencing the response to vaccination when animals failed to reach a rabies antibody titre of ≥ 0.5 IU/ml. Another aim was to assess the level of protection afforded by a commercial veterinary rabies vaccine against intra

SUBMITTER: Nokireki T 

PROVIDER: S-EPMC5625686 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature