Transplacental transfer of maternal respiratory syncytial virus (RSV) antibody and protection against RSV disease in infants in rural Nepal.

ABSTRACT:

Background

Respiratory syncytial virus (RSV) is the most important viral cause of pneumonia in children. RSV-specific antibody (ab) protects infants from disease, and may be increased by a potential strategy of maternal RSV vaccination.

Objectives

To describe the effect of RSV antibody on RSV infection risk in infants in a resource-limited setting.

Study design

In a prospective study in Nepal, women were enrolled during pregnancy and maternal and infant cord blood were collected at birth. Weekly surveillance for respiratory illness was performed from birth to 180days. Nasal swabs were tested for RSV by PCR and serum was tested using an RSV antibody microneutralization assay. Antibody concentrations at time of RSV infection were estimated based on a decay rate of 0.026

SUBMITTER: Chu HY 

PROVIDER: S-EPMC5625849 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature