Network of microbial and antibiotic interactions drive colonization and infection with multidrug-resistant organisms.

ABSTRACT: The emergence and spread of multidrug-resistant organisms (MDROs) across global healthcare networks poses a serious threat to hospitalized individuals. Strategies to limit the emergence and spread of MDROs include oversight to decrease selective pressure for MDROs by promoting appropriate antibiotic use via antibiotic stewardship programs. However, restricting the use of one antibiotic often requires a compensatory increase in the use of other antibiotics, which in turn selects for the emergence of different MDRO species. Further, the downstream effects of antibiotic treatment decisions may also be influenced by functional interactions among different MDRO species, with the potential clinical implications of such interactions remaining largely unexplored. Here, we attempt to decipher the i

SUBMITTER: Wang J 

PROVIDER: S-EPMC5625923 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature