In-utero exposure to antihypertensive medication and neonatal and child health outcomes: a systematic review.

ABSTRACT:

Background

Although medication is generally avoided wherever possible during pregnancy, pharmacotherapy is required for the treatment of pregnancy associated hypertension, which remains a leading cause of maternal and fetal morbidity and mortality. The long-term effects to the child of in-utero exposure to antihypertensive agents remains largely unknown.

Objective

The aim of this study was to systematically review published studies on adverse outcomes to the child associated with in-utero exposure to antihypertensive medications.

Methods

OVID, Scopus, EBSCO Collections, the Cochrane Library, and Web of Science databases were searched for relevant publications published between January 1950 and October 2016 and a total of 688 potentially eligible studies were identifie

SUBMITTER: Fitton CA 

PROVIDER: S-EPMC5625961 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature