Prostaglandin E₂ stimulates adaptive IL-22 production and promotes allergic contact dermatitis.

ABSTRACT:

Background

Atopic dermatitis (AD) and allergic contact dermatitis (ACD) are both forms of eczema and are common inflammatory skin diseases with a central role of T cell-derived IL-22 in their pathogenesis. Although prostaglandin (PG) E₂ is known to promote inflammation, little is known about its role in processes related to AD and ACD development, including IL-22 upregulation.

Objectives

We sought to investigate whether PGE₂ has a role in IL-22 induction and development of ACD, which has increased prevalence in patients with AD.

Methods

T-cell cultures and in vivo sensitization of mice with haptens were used to assess the role of PGE₂ in IL-22 production. The involvement of PGE₂ receptors and their downstream signals was als

SUBMITTER: Robb CT 

PROVIDER: S-EPMC5626002 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature