Flex-nucleoside analogues - Novel therapeutics against filoviruses.

ABSTRACT: Fleximers, a novel type of flexible nucleoside that have garnered attention due to their unprecedented activity against human coronaviruses, have now exhibited highly promising levels of activity against filoviruses. The Flex-nucleoside was the most potent against recombinant Ebola virus in Huh7 cells with an EC₅₀=2μM, while the McGuigan prodrug was most active against Sudan virus-infected HeLa cells with an EC₅₀ of 7μM.

SUBMITTER: Yates MK 

PROVIDER: S-EPMC5626011 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature