T cells from patients with Parkinson's disease recognize α-synuclein peptides.

ABSTRACT: Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson's disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease. These responses may explain the association of Parkinson's disease with specific major histocompatibility complex alleles.

SUBMITTER: Sulzer D 

PROVIDER: S-EPMC5626019 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature