Reconsidering lactate as a sepsis risk biomarker.

ABSTRACT:

Objectives

There has been renewed interest in lactate as a risk biomarker in sepsis and septic shock. However, the ability of the odds ratio (OR) and change in the area under the receiver operator characteristic curve (AUC-ROC) to assess biomarker added-value has been questioned.

Design, setting and participants

A sepsis cohort was identified from the ICU database of an Australian tertiary referral hospital using APACHE III diagnostic codes. Demographic information, APACHE III scores, 24-hour post-admission patient lactate levels, and hospital mortality were accessed.

Measurements and main results

Hospital mortality was modelled using a base predictive logistic regression model and sequential addition of admission lactate, lactate clearance ([lactateadmission-lactatef

SUBMITTER: Moran JL 

PROVIDER: S-EPMC5626033 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature