Histone deacetylase HDAC1 expression correlates with the progression and prognosis of lung cancer: A meta-analysis.

ABSTRACT:

Background

Histone deacetylase 1 (HDAC1) is an important epigenetic factor, and is thought to be associated with the progression and prognosis of some types of cancer. HDAC1 has been reported to be overexpressed in lung cancer, but the correlation between HDAC1 overexpression and the clinical features or prognosis of lung cancer is controversial. In this study, we investigated the potential association between HDAC1 and lung cancer.

Materials and methods

Embase, Web of Science, PubMed, and other sources were searched for relevant studies. Pooled odds ratios (ORs) or hazard ratios (HRs) with 95% confidence interval (CI) were calculated to evaluate the association of HDAC1 with lung cancer risk.

Results

Eight eligible studies were included in the final meta-analysis. We

SUBMITTER: Cao LL 

PROVIDER: S-EPMC5626141 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature