Pregabalin can decrease acute pain and postoperative nausea and vomiting in hysterectomy: A meta-analysis.

ABSTRACT:

Background

Whether the preoperative administration of pregabalin plays a beneficial role in controlling acute pain after hysterectomy is unknown. We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) to determine the efficacy and safety of the preoperative use of pregabalin to treat acute postoperative pain following hysterectomy.

Methods

In April 2017, a systematic computer-based search was conducted in the PubMed, EMBASE, Web of Science, Cochrane Library, and Google databases. RCTs comparing pregabalin with placebo in patients undergoing hysterectomy were retrieved. The primary endpoint was the visual analog scale (VAS) score with rest or mobilization at 2 h, 4 and 24 hours and cumulative morphine consumption at 2, 4, 24, and 48 hours. T

SUBMITTER: Wang YM 

PROVIDER: S-EPMC5626165 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature