Variation of Burkholderia cenocepacia virulence potential during cystic fibrosis chronic lung infection.

ABSTRACT: During long-term lung infection in cystic fibrosis (CF) patients, Burkholderia cenocepacia faces multiple selective pressures in this highly stressful and fluctuating environment. As a consequence, the initial infecting strain undergoes genetic changes that result in the diversification of genotypes and phenotypes. Whether this clonal expansion influences the pathogenic potential is unclear. The virulence potential of 39 sequential B. cenocepacia (recA lineage IIIA) isolates, corresponding to 3 different clones retrieved from 3 chronically infected CF patients was compared in this study using the non-mammalian infection hosts Galleria mellonella and Caenorhabditis elegans. The isolates used in this retrospective study were picked randomly from selective agar plates as part of a CF Center r

SUBMITTER: Moreira AS 

PROVIDER: S-EPMC5626231 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature