Secretome analysis of Trypanosoma cruzi by proteomics studies.

ABSTRACT:

Background

Chagas disease is a debilitating often fatal disease resulting from infection by the protozoan parasite Trypanosoma cruzi. Chagas disease is endemic in 21 countries of the Americas, and it is an emerging disease in other countries as a result of migration. Given the chronic nature of the infection where intracellular parasites persist for years, the diagnosis of T. cruzi by direct detection is difficult, whereas serologic tests though sensitive may yield false-positive results. The development of new rapid test based on the identification of soluble parasitic antigens in serum would be a real innovation in the diagnosis of Chagas disease.

Methods

To identify new soluble biomarkers that may improve diagnostic tests, we investigated the proteins secreted by T. cruzi

SUBMITTER: Brossas JY 

PROVIDER: S-EPMC5626432 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature