Spatiotemporal network coding of physiological mossy fiber inputs by the cerebellar granular layer.

ABSTRACT: The granular layer, which mainly consists of granule and Golgi cells, is the first stage of the cerebellar cortex and processes spatiotemporal information transmitted by mossy fiber inputs with a wide variety of firing patterns. To study its dynamics at multiple time scales in response to inputs approximating real spatiotemporal patterns, we constructed a large-scale 3D network model of the granular layer. Patterned mossy fiber activity induces rhythmic Golgi cell activity that is synchronized by shared parallel fiber input and by gap junctions. This leads to long distance synchrony of Golgi cells along the transverse axis, powerfully regulating granule cell firing by imposing inhibition during a specific time window. The essential network mechanisms, including tunable Golgi cell oscillati

SUBMITTER: Sudhakar SK 

PROVIDER: S-EPMC5626500 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature