Chromatin-Associated Protein SIN3B Prevents Prostate Cancer Progression by Inducing Senescence.

ABSTRACT: Distinguishing between indolent and aggressive prostate adenocarcinoma remains a priority to accurately identify patients who need therapeutic intervention. SIN3B has been implicated in the initiation of senescence in vitro Here we show that in a mouse model of prostate cancer, SIN3B provides a barrier to malignant progression. SIN3B was required for PTEN-induced cellular senescence and prevented progression to invasive prostate adenocarcinoma. Furthermore, SIN3B was downregulated in human prostate adenocarcinoma correlating with upregulation of its target genes. Our results suggest a tumor suppressor function for SIN3B that limits prostate adenocarcinoma progression, with potential implications for the use of SIN3B and its target genes as candidate diagnostic markers to distinguish

SUBMITTER: Bainor AJ 

PROVIDER: S-EPMC5626631 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature