Trastuzumab Increases HER2 Uptake and Cross-Presentation by Dendritic Cells.

ABSTRACT: Early-phase clinical trials evaluating CD8⁺ T cell-eliciting, HER2-derived peptide vaccines administered to HER2⁺ breast cancer patients in the adjuvant setting suggest synergy between the vaccines and trastuzumab, the mAb targeting the HER2 protein. Among 60 patients enrolled in clinical trials evaluating the E75 + GM-CSF and GP2 + GM-CSF vaccines, there have been no recurrences in patients vaccinated after receiving trastuzumab as part of standard therapy in the per treatment analyses conducted after a median follow-up of greater than 34 months. Here, we describe a mechanism by which this synergy may occur. Flow cytometry showed that trastuzumab facilitated uptake of HER2 by dendritic cells (DC), which was mediated by the Fc receptor and was specific to trastuzumab.

SUBMITTER: Gall VA 

PROVIDER: S-EPMC5626640 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature