Succinate promotes stem cell migration through the GPR91-dependent regulation of DRP1-mediated mitochondrial fission.

ABSTRACT: The role of metabolites produced from stem cell metabolism has been emerged as signaling molecules to regulate stem cell behaviors such as migration. The mitochondrial morphology is closely associated with the metabolic balance and stem cell function. However, the physiological role of succinate on human mesenchymal stem cell (hMSC) migration by regulating the mitochondrial morphology remains unclear. Here, we investigate the effect of succinate on hMSC migration via regulation of mitochondrial dynamics and its related signaling pathway. Succinate (50 μM) significantly accelerates hMSC migration. Succinate increases phosphorylation of pan-PKC, especially the atypical PKCζ level which was blocked by the knockdown of Gα_q and Gα_12. Activated PKCζ subsequently phosphoryla

SUBMITTER: Ko SH 

PROVIDER: S-EPMC5626702 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature