Maternal Gestational Diabetes Mellitus increases placental and foetal lipoprotein-associated Phospholipase A2 which might exert protective functions against oxidative stress.

ABSTRACT: Increased Lipoprotein associated phospholipase A₂ (LpPLA₂) has been associated with inflammatory pathologies, including Type 2 Diabetes. Studies on LpPLA₂ and Gestational Diabetes Mellitus (GDM) are rare, and have focused mostly on maternal outcome. In the present study, we investigated whether LpPLA₂ activity on foetal lipoproteins is altered by maternal GDM and/or obesity (a major risk factor for GDM), thereby contributing to changes in lipoprotein functionality. We identified HDL as the major carrier of LpPLA₂ activity in the foetus, which is in contrast to adults. We observed marked expression of LpPLA₂ in placental macrophages (Hofbauer cells; HBCs) and found that LpPLA₂ activity in these cells was increased

SUBMITTER: Schliefsteiner C 

PROVIDER: S-EPMC5626711 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature