Intermediate and low abundant protein analysis of vitamin D deficient obese and non-obese subjects by MALDI-profiling.

ABSTRACT: Obesity is a pathological condition caused by genetic and environmental factors, including vitamin D deficiency, which increases the risk of developing cardiovascular disorders and diabetes. This case-control study was designed to verify whether serum profiles could be identified differentiating obese and non-obese Saudis characterized by vitamin D deficiency and pathological levels of triglycerides, high-density lipoprotein cholesterol and high total cholesterol levels. The serum protein profiles of 64 vitamin D deficient (serum 25(OH)D < 50nmol/L) individuals with metabolic syndrome and with (n = 31; BMI ≥ 30) or without (n = 33; BMI < 30) obesity were analyzed by a quantitative label-free mass spectrometry approach (MALDI-profiling), combined with different serum immunodepletion strateg

SUBMITTER: Al-Daghri NM 

PROVIDER: S-EPMC5626753 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature