The Bacterial Species <i>Campylobacter jejuni</i> Induce Diverse Innate Immune Responses in Human and Avian Intestinal Epithelial Cells.

ABSTRACT: Campylobacter remain the major cause of human gastroenteritis in the Developed World causing a significant burden to health services. Campylobacter are pathogens in humans and chickens, although differences in mechanistic understanding are incomplete, in part because phenotypic strain diversity creates inconsistent findings. Here, we took Campylobacter jejuni isolates (n = 100) from multi-locus sequence typed collections to assess their pathogenic diversity, through their inflammatory, cytotoxicity, adhesion, invasion and signaling responses in a high-throughput model using avian and human intestinal epithelial cells. C. jejuni induced IL-8 and CXCLi1/2 in human and avian epithelial cells, respectively, in a MAP kinase-dependent manner. In contrast, IL-10

SUBMITTER: John DA 

PROVIDER: S-EPMC5626877 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature