Region-specific RNA m⁶A methylation represents a new layer of control in the gene regulatory network in the mouse brain.

ABSTRACT: N⁶-methyladenosine (m⁶A) is the most abundant epitranscriptomic mark found on mRNA and has important roles in various physiological processes. Despite the relatively high m⁶A levels in the brain, its potential functions in the brain remain largely unexplored. We performed a transcriptome-wide methylation analysis using the mouse brain to depict its region-specific methylation profile. RNA methylation levels in mouse cerebellum are generally higher than those in the cerebral cortex. Heterogeneity of RNA methylation exists across different brain regions and different types of neural cells including the mRNAs to be methylated, their methylation levels and methylation site selection. Common and region-specific methylation have different preferences for methylat

SUBMITTER: Chang M 

PROVIDER: S-EPMC5627058 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature