Sweepstake evolution revealed by population-genetic analysis of copy-number alterations in single genomes of breast cancer.

ABSTRACT: Single-cell sequencing is a promising technology that can address cancer cell evolution by identifying genetic alterations in individual cells. In a recent study, genome-wide DNA copy numbers of single cells were accurately quantified by single-cell sequencing in breast cancers. Phylogenetic-tree analysis revealed genetically distinct populations, each consisting of homogeneous cells. Bioinformatics methods based on population genetics should be further developed to quantitatively analyse the single-cell sequencing data. We developed a bioinformatics framework that was combined with molecular-evolution theories to analyse copy-number losses. This analysis revealed that most deletions in the breast cancers at the single-cell level were generated by simple stochastic processes. A non-standar

SUBMITTER: Kato M 

PROVIDER: S-EPMC5627131 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature