Cellular Contraction Can Drive Rapid Epithelial Flows.

ABSTRACT: Single, isolated epithelial cells move randomly; however, during wound healing, organism development, cancer metastasis, and many other multicellular phenomena, motile cells group into a collective and migrate persistently in a directed manner. Recent work has examined the physics and biochemistry that coordinates the motions of these groups of cells. Of late, two mechanisms have been touted as being crucial to the physics of these systems: leader cells and jamming. However, the actual importance of these to collective migration remains circumstantial. Fundamentally, collective behavior must arise from the actions of individual cells. Here, we show how biophysical activity of an isolated cell impacts collective dynamics in epithelial layers. Although many reports suggest that wound closure

SUBMITTER: Vig DK 

PROVIDER: S-EPMC5627147 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature