Acetylated Microtubules Are Preferentially Bundled Leading to Enhanced Kinesin-1 Motility.

ABSTRACT: The motor proteins kinesin and dynein transport organelles, mRNA, proteins, and signaling molecules along the microtubule cytoskeleton. In addition to serving as tracks for transport, the microtubule cytoskeleton directs intracellular trafficking by regulating the activity of motor proteins through the organization of the filament network, microtubule-associated proteins, and tubulin posttranslational modifications. However, it is not well understood how these factors influence motor motility, and in vitro assays and live cell observations often produce disparate results. To systematically examine the factors that contribute to cytoskeleton-based regulation of motor protein motility, we extracted intact microtubule networks from cells and tracked the motility of single fluorescently labele

SUBMITTER: Balabanian L 

PROVIDER: S-EPMC5627185 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature