Analysis of a Functional Dimer Model of Ubiquinol Cytochrome c Oxidoreductase.

ABSTRACT: Ubiquinol cytochrome c oxidoreductase (bc₁ complex) serves as an important electron junction in many respiratory systems. It funnels electrons coming from NADH and ubiquinol to cytochrome c, but it is also capable of producing significant amounts of the free radical superoxide. In situ and in other experimental systems, the enzyme exists as a dimer. But until recently, it was believed to operate as a functional monomer. Here we show that a functional dimer model is capable of explaining both kinetic and superoxide production rate data. The model consists of six electronic states characterized by the number of electrons deposited on the complex. It is fully reversible and strictly adheres to the thermodynamics governing the reactions. A total of nine independent data sets were us

SUBMITTER: Bazil JN 

PROVIDER: S-EPMC5627346 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature