DNA Methylation Landscape Reflects the Spatial Organization of Chromatin in Different Cells.

ABSTRACT: The relationship between DNA methylation and chromatin structure is still largely unknown. By analyzing a large set of published sequencing data, we observed a long-range power law correlation of DNA methylation with cell class-specific scaling exponents in the range of tens of kilobases. We showed that such cell class-specific scaling exponents are caused by different patchiness of DNA methylation in different cells. By modeling the chromatin structure using high-resolution chromosome conformation capture data and mapping the methylation level onto the modeled structure, we demonstrated that the patchiness of DNA methylation is related to chromatin structure. The scaling exponents of the power law correlation are thus a display of the spatial organization of chromatin. Besides the long-ra

SUBMITTER: Zhang L 

PROVIDER: S-EPMC5627392 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature