Epigenome alterations in aortic valve stenosis and its related left ventricular hypertrophy.

ABSTRACT: Aortic valve stenosis is the most common cardiac valve disease, and with current trends in the population demographics, its prevalence is likely to rise, thus posing a major health and economic burden facing the worldwide societies. Over the past decade, it has become more than clear that our traditional genetic views do not sufficiently explain the well-known link between AS, proatherogenic risk factors, flow-induced mechanical forces, and disease-prone environmental influences. Recent breakthroughs in the field of epigenetics offer us a new perspective on gene regulation, which has broadened our perspective on etiology of aortic stenosis and other aortic valve diseases. Since all known epigenetic marks are potentially reversible this perspective is especially exciting given the potential

SUBMITTER: Gosev I 

PROVIDER: S-EPMC5627415 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature