Exosomes of human placenta-derived mesenchymal stem cells stimulate angiogenesis.

ABSTRACT:

Background

The therapeutic potential of mesenchymal stem cells (MSCs) may be attributed partly to humoral factors such as growth factors, cytokines, and chemokines. Human term placental tissue-derived MSCs (PlaMSCs), or conditioned medium left over from cultures of these cells, have been reported to enhance angiogenesis. Recently, the exosome, which can transport a diverse suite of macromolecules, has gained attention as a novel intercellular communication tool. However, the potential role of the exosome in PlaMSC therapeutic action is not well understood. The purpose of this study was to evaluate PlaMSC-derived exosome angiogenesis promotion in vitro and in vivo.

Methods

MSCs were isolated from human term placental tissue by enzymatic digestion. Conditioned medium was colle

SUBMITTER: Komaki M 

PROVIDER: S-EPMC5627451 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature