Analysis of SNP-SNP interactions and bone quantitative ultrasound parameter in early adulthood.

ABSTRACT:

Background

Osteoporosis individual susceptibility is determined by the interaction of multiple genetic variants and environmental factors. The aim of this study was to conduct SNP-SNP interaction analyses in candidate genes influencing heel quantitative ultrasound (QUS) parameter in early adulthood to identify novel insights into the mechanism of disease.

Methods

The study population included 575 healthy subjects (mean age 20.41; SD 2.36). To assess bone mass QUS was performed to determine Broadband ultrasound attenuation (BUA, dB/MHz). A total of 32 SNPs mapping to loci that have been characterized as genetic markers for QUS and/or BMD parameters were selected as genetic markers in this study. The association of all possible SNP pairs with QUS was assessed by linear regress

SUBMITTER: Correa-Rodriguez M 

PROVIDER: S-EPMC5627468 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature