ConfFuse: High-Confidence Fusion Gene Detection across Tumor Entities.

ABSTRACT: Background: Fusion genes play an important role in the tumorigenesis of many cancers. Next-generation sequencing (NGS) technologies have been successfully applied in fusion gene detection for the last several years, and a number of NGS-based tools have been developed for identifying fusion genes during this period. Most fusion gene detection tools based on RNA-seq data report a large number of candidates (mostly false positives), making it hard to prioritize candidates for experimental validation and further analysis. Selection of reliable fusion genes for downstream analysis becomes very important in cancer research. We therefore developed confFuse, a scoring algorithm to reliably select high-confidence fusion genes which are likely to be biologically relevant. Results: confFuse takes mul

SUBMITTER: Huang Z 

PROVIDER: S-EPMC5627533 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature