Association between the rs1042522 polymorphism in TP53 and prostate cancer risk: An updated meta-analysis.

ABSTRACT:

Objective

The proposal of the present study was to investigate whether the TP53 rs1042522 polymorphism confers susceptibility to prostate cancer (PCa), by performing an updated meta-analysis.

Methods

Eligible publications investigating the association between the TP53 rs1042522 polymorphism and PCa susceptibility were selected from PubMed, Google Scholar, and Web of Science. We used STATA 12.0 software to conduct the analyses. Odds ratio (OR) with 95% confidence interval (CI) was calculated.

Results

A total of 17 case-control studies were retrieved reporting a total of 2683 cases and 2981 controls. However, no significant association was uncovered between the TP53 rs1042522 polymorphism and PCa susceptibility in the overall populatio

SUBMITTER: Fan S 

PROVIDER: S-EPMC5627694 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature