Characterization of colloidal structures during intestinal lipolysis using small-angle neutron scattering.

ABSTRACT:

Hypothesis

Bile micelles are thought to mediate intestinal absorption, in part by providing a phase into which compounds can partition. Solubilizing capacity of bile micelles is enhanced during the digestion of fat rich food. We hypothesized that the intestinal digestion of triglycerides causes an increase in volume of micelles that can be quantitatively monitored over the course of digestion using small-angle neutron scattering (SANS), and that SANS can enable evaluation of the contribution of each of the components present during digestion to the size of micelles.

Experiments

SANS was used to characterize the size and shape of micelles present prior to and during the in vitro simulated intestinal digestion of a model food-associated lipid, triolein.

Findings

Pre-lip

SUBMITTER: Rezhdo O 

PROVIDER: S-EPMC5627765 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature