Ontology highlight
ABSTRACT:
SUBMITTER: Lee JK
PROVIDER: S-EPMC5627771 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Nature genetics 20170306 4
Precision medicine in cancer proposes that genomic characterization of tumors can inform personalized targeted therapies. However, this proposition is complicated by spatial and temporal heterogeneity. Here we study genomic and expression profiles across 127 multisector or longitudinal specimens from 52 individuals with glioblastoma (GBM). Using bulk and single-cell data, we find that samples from the same tumor mass share genomic and expression signatures, whereas geographically separated, mult ...[more]