Continuous Intestinal Absorption Model Based on the Convection-Diffusion Equation.

ABSTRACT: Prediction of the rate and extent of drug absorption upon oral dosing needs models that capture the complexities of both the drug molecule and intestinal physiology. We report here the development of a continuous intestinal absorption model based on the convection-diffusion equation. The model includes explicit enterocyte apical membrane and intracellular lipid radial compartments along the length of the intestine. Physiologic functions along length x are built into the model and include velocity, diffusion, surface areas, and pH of the intestine. Also included are expression levels of the intestinal active uptake transporter OATP2B1 and efflux transporter P-gp. Oral dosing of solution as well as solid (with a dissolution function) was modeled for several drugs. The fraction absorbed (FA)

SUBMITTER: Nagar S 

PROVIDER: S-EPMC5627780 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature