Ontology highlight
ABSTRACT:
SUBMITTER: Shlezinger N
PROVIDER: S-EPMC5628051 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Shlezinger Neta N Irmer Henriette H Dhingra Sourabh S Beattie Sarah R SR Cramer Robert A RA Braus Gerhard H GH Sharon Amir A Hohl Tobias M TM
Science (New York, N.Y.) 20170901 6355
Humans inhale mold conidia daily and typically experience lifelong asymptomatic clearance. Conidial germination into tissue-invasive hyphae can occur in individuals with defects in myeloid function, although the mechanism of myeloid cell-mediated immune surveillance remains unclear. By monitoring fungal physiology in vivo, we demonstrate that lung neutrophils trigger programmed cell death with apoptosis-like features in <i>Aspergillus fumigatus</i> conidia, the most prevalent human mold pathogen ...[more]