Long-term use of antibiotics and risk of colorectal adenoma.

ABSTRACT:

Objective

Recent evidence suggests that antibiotic use, which alters the gut microbiome, is associated with an increased risk of colorectal cancer. However, the association between antibiotic use and risk of colorectal adenoma, the precursor for the majority of colorectal cancers, has not been investigated.

Design

We prospectively evaluated the association between antibiotic use at age 20-39 and 40-59 (assessed in 2004) and recent antibiotic use (assessed in 2008) with risk of subsequent colorectal adenoma among 16 642 women aged ≥60 enrolled in the Nurses' Health Study who underwent at least one colonoscopy through 2010. We used multivariate logistic regression to calculate ORs and 95% CIs.

Results

We documented 1195 cases of adenoma. Increasing duration of antibioti

SUBMITTER: Cao Y 

PROVIDER: S-EPMC5628103 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature