Neonatal mice possess two phenotypically and functionally distinct lung-migratory CD103⁺ dendritic cell populations following respiratory infection.

ABSTRACT: The CD103⁺ subset of lung-migratory dendritic cells (DCs) plays an important role in the generation of CD8⁺ T cell responses following respiratory infection. Here, we demonstrate that the dependence on CD103⁺ DCs for stimulation of RSV-specific T cells is both epitope and age-dependent. CD103⁺ DCs in neonatal mice develop two phenotypically and functionally distinct populations following respiratory infection. Neonatal CD103⁺ DCs expressing low levels of CD103 (CD103lo DCs) and other lineage and maturation markers including costimulatory molecules are phenotypically immature and functionally limited. CD103lo DCs sorted from infected neonates were unable to stimulate cells of the K^dM2_82-90 specificity, which are po

SUBMITTER: Ruckwardt TJ 

PROVIDER: S-EPMC5628111 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature