Korean Red Ginseng extract induces angiogenesis through activation of glucocorticoid receptor.

ABSTRACT:

Background

Our previous studies have demonstrated that ginsenoside-Rg1 can promote angiogenesis in vitro and in vivo through activation of the glucocorticoid receptor (GR). Furthermore, microRNA (miRNA) expression profiling has shown that Rg1 can modulate the expression of a subset of miRNAs to induce angiogenesis. Moreover, Rb1 was shown to be antiangiogenic through activation of a different pathway. These studies highlight the important functions of miRNAs on ginseng-regulated physiological processes. The aim of this study was to determine the angiogenic properties of Korean Red Ginseng extract (KGE).

Methods and results

Combining in vitro and in vivo data, KGE at 500 μg/mL was found to induce angiogenesis. According to the miRNA sequencing, 484

SUBMITTER: Sung WN 

PROVIDER: S-EPMC5628332 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature