Impact of supplementation with a food-derived microbial community on obesity-associated inflammation and gut microbiota composition.

ABSTRACT:

Background

Obesity is a complex pathology associated with dysbiosis, metabolic alterations, and low-grade chronic inflammation promoted by immune cells, infiltrating and populating the adipose tissue. Probiotic supplementation was suggested to be capable of counteracting obesity-associated immune and microbial alterations, based on its proven immunomodulatory activity and positive effect on gut microbial balance. Traditional fermented foods represent a natural source of live microbes, including environmental strains with probiotic features, which could transiently colonise the gut. The aim of our work was to evaluate the impact of supplementation with a complex foodborne bacterial consortium on obesity-associated inflammation and gut microbiota composition in a mouse model.

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SUBMITTER: Roselli M 

PROVIDER: S-EPMC5628415 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature