N-truncated Aβ_4-x peptides in sporadic Alzheimer's disease cases and transgenic Alzheimer mouse models.

ABSTRACT:

Background

The deposition of neurotoxic amyloid-β (Aβ) peptides in plaques in the brain parenchyma and in cerebral blood vessels is considered to be a key event in Alzheimer's disease (AD) pathogenesis. Although the presence and impact of full-length Aβ peptides such as Aβ_1-40 and Aβ_1-42 have been analyzed extensively, the deposition of N-terminally truncated Aβ peptide species has received much less attention, largely because of the lack of specific antibodies.

Methods

This paper describes the generation and characterization of novel antibodies selective for Aβ_4-x peptides and provides immunohistochemical evidence of Aβ_4-x in the human brain and its distribution in the APP/PS1KI and 5XFAD transgenic mouse models.

Results

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SUBMITTER: Wirths O 

PROVIDER: S-EPMC5628465 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature