Nanostructured Mineral Coatings Stabilize Proteins for Therapeutic Delivery.

ABSTRACT: Proteins tend to lose their biological activity due to their fragile structural conformation during formulation, storage, and delivery. Thus, the inability to stabilize proteins in controlled-release systems represents a major obstacle in drug delivery. Here, a bone mineral inspired protein stabilization strategy is presented, which uses nanostructured mineral coatings on medical devices. Proteins bound within the nanostructured coatings demonstrate enhanced stability against extreme external stressors, including organic solvents, proteases, and ethylene oxide gas sterilization. The protein stabilization effect is attributed to the maintenance of protein conformational structure, which is closely related to the nanoscale feature sizes of the mineral coatings. Basic fibroblast growth factor

SUBMITTER: Yu X 

PROVIDER: S-EPMC5628619 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature