Loop ileostomy-mediated fecal stream diversion is associated with microbial dysbiosis.

ABSTRACT: Loop ileostomy is an effective procedure to protect downstream intestinal anastomoses. Ileostomy reversal surgery is often performed within 12 months of formation but is associated with substantial morbidity due to severe post-surgical complications. Distal ileum is deprived of enteral nutrition and rendered inactive, often becoming atrophied and fibrotic. This study aimed to investigate the microbial and morphological changes that occur in the defunctioned ileum following loop ileostomy-mediated fecal stream diversion. Functional and defunctioned ileal resection tissue was obtained at the time of loop-ileostomy closure. Intrapatient comparisons, including histological assessment of morphology and epithelial cell proliferation, were performed on paired samples using the functional limb as

SUBMITTER: Beamish EL 

PROVIDER: S-EPMC5628638 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature