Magnetic Resonance Elastography to Assess Fibrosis in Kidney Allografts.

ABSTRACT:

Background and objectives

Fibrosis is a major cause of kidney allograft injury. Currently, the only means of assessing allograft fibrosis is by biopsy, an invasive procedure that samples <1% of the kidney. We examined whether magnetic resonance elastography, an imaging-based measure of organ stiffness, could noninvasively estimate allograft fibrosis and predict progression of allograft dysfunction.

Design, setting, participants, & measurements

Kidney allograft recipients >1 year post-transplant undergoing an allograft biopsy first underwent free-breathing, flow-compensated magnetic resonance elastography on a 3.0-T magnetic resonance imaging scanner. Each patient had serial eGFR measurements after the elastography scan for a follow-up period of up to 1 year. The mean stiffne

SUBMITTER: Kirpalani A 

PROVIDER: S-EPMC5628708 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature