Uptake and release of amino acids in the fetal-placental unit in human pregnancies.

ABSTRACT:

Objectives

The current concepts of human fetal-placental amino acid exchange and metabolism are mainly based on animal-, in vitro- and ex vivo models. We aimed to determine and assess the paired relationships between concentrations and arteriovenous differences of 19 amino acids on the maternal and fetal sides of the human placenta in a large study sample.

Methods

This cross-sectional in vivo study included 179 healthy women with uncomplicated term pregnancies. During planned cesarean section, we sampled blood from incoming and outgoing vessels on the maternal (radial artery and uterine vein) and fetal (umbilical vein and artery) sides of the placenta. Amino acid concentrations were measured by liquid chromatography-tandem mass spectrometry. We calculated paired arteriovenou

SUBMITTER: Holm MB 

PROVIDER: S-EPMC5628923 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature