Subphenotypes of inflammatory bowel disease are characterized by specific serum protein profiles.

ABSTRACT:

Objective

Genetic and immunological data indicate that inflammatory bowel disease (IBD) are characterized by specific inflammatory protein profiles. However, the serum proteome of IBD is still to be defined. We aimed to characterize the inflammatory serum protein profiles of Crohn's disease (CD) and ulcerative colitis (UC), using the novel proximity extension assay.

Methods

A panel of 91 inflammatory proteins were quantified in a discovery cohort of CD (n = 54), UC patients (n = 54), and healthy controls (HCs; n = 54). We performed univariate analyses by t-test, with false discovery rate correction. A sparse partial least-squares (sPLS) approach was used to identify additional discriminative proteins. The results were validated in a replication cohort.

Results

By univ

SUBMITTER: Andersson E 

PROVIDER: S-EPMC5628935 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature