New insights into experimental visceral leishmaniasis: Real-time in vivo imaging of Leishmania donovani virulence.

ABSTRACT: Visceral leishmaniasis is an insidious neglected disease with worldwide distribution. It is caused by parasites from the Leishmania donovani complex, which are able to be transmitted by different species of phlebotomine sand flies and to infect numerous mammal hosts. Despite the high number of people infected or at risk, and the remarkable quantity of studies focusing on this disease, a proper experimental model to efficiently decipher the infectious process of visceral leishmaniasis taking into account the nuances of parasite’s virulence and the duration of the infection is still lacking. Therefore, using golden Syrian hamsters and BALB/c mice, state-of-the-art genetic manipulation applied on a fully virulent L. donovani strain and in vivo imaging approaches, we describe herein three bene

SUBMITTER: Melo GD 

PROVIDER: S-EPMC5629011 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature