Effects of schistosomiasis on susceptibility to HIV-1 infection and HIV-1 viral load at HIV-1 seroconversion: A nested case-control study.

ABSTRACT:

Background

Schistosomiasis affects 218 million people worldwide, with most infections in Africa. Prevalence studies suggest that people with chronic schistosomiasis may have higher risk of HIV-1 acquisition and impaired ability to control HIV-1 replication once infected. We hypothesized that: (1) pre-existing schistosome infection may increase the odds of HIV-1 acquisition and that the effects may differ between men and women, and (2) individuals with active schistosome infection at the time of HIV-1 acquisition may have impaired immune control of HIV-1, resulting in higher HIV-1 viral loads at HIV-1 seroconversion.

Methodology/principal findings

We conducted a nested case-control study within a large population-based survey of HIV-1 transmission in Tanzania. A population of

SUBMITTER: Downs JA 

PROVIDER: S-EPMC5629028 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature