Impact of Enterobius vermicularis infection and mebendazole treatment on intestinal microbiota and host immune response.

ABSTRACT:

Background

Previous studies on the association of enterobiasis and chronic inflammatory diseases have revealed contradictory results. The interaction of Enterobius vermicularis infection in particular with gut microbiota and induced immune responses has never been thoroughly examined.

Methodology/findings

In order to answer the question of whether exposure to pinworm and mebendazole can shift the intestinal microbial composition and immune responses, we recruited 109 (30 pinworm-negative, 79 pinworm-infected) first and fourth grade primary school children in Taichung, Taiwan, for a gut microbiome study and an intestinal cytokine and SIgA analysis. In the pinworm-infected individuals, fecal samples were collected again at 2 weeks after administration of 100 mg mebendazole. Gu

SUBMITTER: Yang CA 

PROVIDER: S-EPMC5629029 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature