Epidemiology of vulvar neoplasia in the NIH-AARP Study.

ABSTRACT:

Objective

To clarify risk factors for rare vulvar neoplasms.

Methods

Within the NIH-AARP Study, among 201,469 women interviewed in 1995-1996 and followed for a mean of 13.8years, there were 370 diagnoses of incident vulvar neoplasms, including 170 invasive and 198 vulvar intraepithelial neoplasms grade 3 (VIN3). Hazard ratios (HR) and 95% confidence intervals (CI) were calculated via multivariate logistic regression for various demographic, reproductive and lifestyle factors, with separate consideration of relations according to invasiveness, histology and age at diagnosis.

Results

Consistent with descriptive data, we found non-white women at lower risks of vulvar neoplasia than white women (HR=0.59, 95% CI 0.36-0.95). Significant risk factors for VIN3 included being

SUBMITTER: Brinton LA 

PROVIDER: S-EPMC5629039 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature